Palindromic rheumatism (pal-in-drom-ic roo-ma-tiz-em) is a form of inflammatory arthritis. It causes attacks or flare-ups of joint pain and inflammation that come and go. The joints look and feel normal between attacks, and the attacks don’t cause any lasting damage to the joints. Palindromic rheumatism affects both men and women equally and typically affects people between the ages of 20 and 50.
Symptoms of AiArthritis Diseases Regardless of Diagnosis
“Auto” Symptoms
Reference: Early Symptoms of AiArthritis Study, AiArthritis, 2019.
Typically the joint pain will coincide with one or more “Auto” symptoms and start and stop suddenly - for no apparent reason (which is called a "flare"). Some people will experience all of the above symptoms, others only a few. If you have any of the arthritis features, and at least one of the “Auto” features, please consult your physician about a referral to a rheumatologist.
Symptoms Often Associated with Palindromic Rheumatism:
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There’s no single definitive test that can confirm a palindromic rheumatism diagnosis, so rheumatologists look at a combination of physical exam, blood tests (ESR, CRP, antibody tests), and imaging (x-ray), along with a family history of autoimmune or autoinflammatory disease. It is important to try to get tests and imaging done during an attack or flare since the symptoms are intermittent. If unable to get to a doctor during the attack, documenting symptoms with pictures and logs is essential.
In an effort to ensure this page has the most accurate and up-to-date information, this page is currently awaiting medical review. Some information is subject to change.
Page Last Updated: 9/1/2023
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