Antisynthetase syndrome is a rare, chronic auto-immune disorder that can affect multiple systems of the body. This disorder is often characterized by having autoantibodies (Anti-Jo1) to a specific protein. It is a form of myositis.
Symptoms of AiArthritis Diseases Regardless of Diagnosis
“Auto” Symptoms
Reference: Early Symptoms of AiArthritis Study, AiArthritis, 2019.
Typically the joint pain will coincide with one or more “Auto” symptoms and start and stop suddenly - for no apparent reason (which is called a "flare"). Some people will experience all of the above symptoms, others only a few. If you have any of the arthritis features, and at least one of the “Auto” features, please consult your physician about a referral to a rheumatologist.
Symptoms Often Associated with Antisynthetase Syndrome:
What fellow patients want you to know
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There’s no single definitive test that can confirm an antisynthetase syndrome diagnosis, so rheumatologists look at a combination of physical exam (pulmonary function tests, electromyography), blood tests (Anti-tRNA antibody), and imaging (high-resolution computed tomography, MRI), along with a family history of autoimmune or autoinflammatory disease. A biopsy of the muscle, or lung may also be required for a definitive diagnosis.
In an effort to ensure this page has the most accurate and up-to-date information, this page is currently awaiting medical review. Some information is subject to change.
Page Last Updated: 9/1/2023
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