Osteomyelitis - os-tee-oh-mEYE-uh-lai-tis
Chronic Nonbacterial Osteomyelitis (CNO)/Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory disease where the bones become inflamed without any bacterial infection. They cause persistent bone pain and swelling, primarily in areas like long bones, pelvis, shoulder, and spine. Cytokines like IL-1β and IL-10 play a role in the disease. This disease is mostly found in children.
Symptoms of AiArthritis Diseases Regardless of Diagnosis
“Auto” Symptoms
Reference: Early Symptoms of AiArthritis Study, AiArthritis, 2019.
Typically the joint pain will coincide with one or more “Auto” symptoms and start and stop suddenly - for no apparent reason (which is called a "flare"). Some people will experience all of the above symptoms, others only a few. If you have any of the arthritis features, and at least one of the “Auto” features, please consult your physician about a referral to a rheumatologist.
Symptoms Often Associated with CNO/CRMO:
What fellow patients want you to know
Do you have CNO/CRMO? Let us know what YOU would want those others or those who are not yet diagnosed to know!
There’s no single definitive test that can confirm a CNO/CRMO diagnosis, so rheumatologists look at a combination of physical exam, blood tests (ESR and CRP), imaging (x-ray, MRI, CT, nuclear bone scan), and bone biopsy along with a family history of autoimmune or autoinflammatory disease. CNO/CRMO diagnosis also includes the exclusion of other possible diseases because the symptoms overlap with several others.
In an effort to ensure this page has the most accurate and up-to-date information, this page is currently awaiting medical review. Some information is subject to change.
Page Last Updated: 9/1/2023
International Foundation for AiArthritis
6605 Nottingham Ave.
St. Louis, MO 63109-2661
Copyright 2024. All rights reserved. Information on this site is intended for informational purposes only Our foundation does not engage in the practice of medicine. Please consult a physician to obtain personal healthcare and treatment options. 501(c) 3 Nonprofit Tax ID: 27-1214308.